Research

I aim to answer pressing clinical questions using research in the comparative pharmacoepidemiology of chronic medications in older adults.

My main therapeutic areas of interest are osteoporosis, diabetes, and hypertension. My methods areas of interest include propensity score methods, causal inference, and self-controlled study designs. I also conduct research on the impacts of drug pricing and policy on medication use, particularly in vulnerable populations.


Featured Publications

  1. Hayes KN, Cheung AM, Brown KJ, Kim SA, Juurlink DN, Cadarette SM. Comparative risks of osteoporosis drug holidays following long-term risedronate versus alendronate therapy: a propensity score-matched cohort study. Published online ahead of print, Ann Intern Med. Jan 11, 2022. PMID: 35007149.
  2. Hayes KN, Winter EM, Cadarette SM, Burden AM. Duration of bisphosphonate drug holidays in osteoporosis patients: a narrative review of the evidence and considerations for decision-making. J Clin Med. 2021;10(5):1140. PMCID: PMC7963175.
  3. Cadarette SM, Maclure M, Delaney JAC, Gagne JJ, Whitaker HJ, Hayes KN, Wang SV, Tadrous M, Gagne JJ, Consiglio GP, Hallas J. Control yourself: ISPE-sponsored guidance for the application of self-controlled study designs in pharmacoepidemiology. Pharmacoepidemiol Drug Saf. 2021;30 (6):671-684. PMCID: PMC8251635.
  4. Hayes KN, Nakhla N, Tadrous M. Further evidence to monitor chronic proton pump inhibitor use. JAMA Netw Open. 2019;2(11):e1916184. PMID: 31774516.

Latest PubMed Indexed Publications


Peer-Reviewed Grants and Training Awards

  1. Canadian Institutes of Health Research (CIHR), Project Grant, 2019 – 2021
    • Comparative benefits and harms of long-term osteoporosis pharmacotherapy
    • PIs: Cadarette SM, Hayes KN; Co-Is: Brown K, Cheung A, Juurlink DN
    • 100,000 CAD (NB: CIHR Grants do not include salary support for investigators)
  2. Canadian Institutes of Health Research Doctoral Research Award, 2019 – 2021
    • 105,000 CAD (90,000 CAD stipend; 15,000 CAD Research Grant)
  3. CIHR Drug Safety and Effectiveness Cross-Disciplinary Training Program Award (2)
    • Stream 1 Training Stipend – 10,000 CAD, 2018
    • Stream 2 Training Stipend – 10,000 CAD, 2020
  4. University of Pittsburgh Full Tuition Merit Undergraduate Scholarship, 94,376 USD, 2011 – 2015 

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